Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers

Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. The investigators propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.

Inclusion Criteria:EDS patients, clinically diagnosed hypermobile EDS based on 2017 criteriaEDS patients with genetically proven non-hypermobile EDSHealthy participants, no EDSAble and willing to provide informed consentExclusion Criteria:Known allergy to LidocaineUnable to provide informed consent