Effects of Mouthrinses on the Microbiome of the Oral Cavity and GI Tract

The purpose of this research study is to identify the effects of 2 over-the-counter mouthwashes on bacteria and 3 viruses in the participant's mouth and gut. The participant will be randomly allocated to rinse their mouth twice daily either with Listerine mouthwash, Lumineux Oral Essentials mouthwash, or water. The overall duration of the study will be approximately 180 days and will include approximately 5 visits and 15-30 minutes for each visit with a total of approximately 2.5 hours of your time. Additionally, fecal matter will also be collected in some subjects using a commercial collection kit.

Inclusion Criteria:Eligible men and non-pregnant and non-lactating women of all races age 18-25.Volunteers must consent to participate in all scheduled exam visits and procedures.Volunteers must be available for follow up on the telephone.Healthy gums or gums that bleed when you brush them.Exclusion Criteria:Volunteers unable or unwilling to sign the informed consent form.Less than 20 teeth (excluding third molars).Individuals who have taken antibiotics in the previous 3 months.Presence of any condition, abnormality, or situation at Baseline that in the opinion of the Principal Investigator may preclude the volunteer's ability to comply with study requirements, including completion of the study or the quality of the data.