Citrulline Supplementation On Vascular Responsiveness and Function in Postmenopausal Women

The objective of this project is to provide evidence that L-Citrulline (L-CIT) supplementation can improve vascular function at rest and in response to exercise in postmenopausal women.

Inclusion Criteria:Postmenopausal (absence of menstruation > 1 year) between the ages of 50 - 79 years.Sedentary ( < 120 minutes of exercise/week)Resting systolic blood pressure < 150 mmHg and diastolic blood pressure < 90 mmHgNot participating as a subject in another study for at least 2 months prior to the study and for the duration of the studyWillingness to abstain from food supplements 1 month prior to the start of the study and throughout the duration of the studyExclusion Criteria:Body mass index ≥ 40Currently taking more than one vasoactive drug for blood pressure controlCardiometabolic diseases or other chronic diseasesTaking hormone replacement therapy 3 months prior to the studyCurrent or prior use of tobacco productsMore than a moderate intake of alcoholUse of medications and/or supplements that may affect outcome variablesMusculoskeletal disorders that will prevent exercise performance