Clinical Trial to Evaluate Effectiveness of a Probiotic Preparation Administered to Patients With Alopecia Areata

This study is part of a broader project that proposes the characterization of what we call the "Entire-Systemic Axis". It aims to study whether the bacteria present in the human skin microbiota and in the human intestinal microbiota can play a role in the pathophysiology of Alopecia Areata (AA), a fact that has not been studied to date. Based on the supposed relationship between the human microbiota and AA, we have formulated the hypothesis that the dietary supplementation of specific probiotic strains, with functional capacities on mucocutaneous tissue and its adnexa, could benefit patients with AA, acting on the patients' microbiome profile.

Inclusion Criteria:AA diagnosis by clinical criteria.Show at least 2 signs of AA activity, visualized by trichoscopySignature of informed consent by the patient, in accordance with the legislation on clinical trials.Exclusion Criteria:Allergies or contraindication to take any of the components of the product under study.Topical or systemic use of antifungals and antibiotics in the previous 2 weeks.Consumption of probiotics in the previous 2 months. - Participation in clinical studies in the previous 2 months.Pregnancy and/or lactation.