Brain Enhancement Training Towards Elders Resilience to Aging, Phase IIB

This study aims to examine the longer-term benefits of a novel, neuroplasticity-based, computerized and web-deliverable training program (PACR-CT) five years from the initial 10 weeks of training from our Phase II study - Protocol #: PSC-0605-17 (Aim 1) and test the interactive effect of previous training and 10 weeks of booster training (Aim 2). Both the study and the software being investigated meet the criteria of Non-Significant Risk.

Inclusion Criteria:Participant must be 70 years of age or olderParticipant must be a fluent English speakerParticipant must have adequate sensorimotor capacity to perform the program, including visual capacity adequate to read from a computer screen at a normal viewing distance, auditory capacity adequate to understand normal speech, and motor capacity adequate to control a computer mouseParticipant must not have evidence of dementia as indicated by the Montreal Cognitive Assessment (MoCA)Exclusion Criteria:Participant with any medical illnesses, injuries or conditions predisposing to imminent functional and/or cognitive declineParticipant requiring caregiver assistance in dressing/personal hygieneParticipant with severe visual deficits (including visual neglect, partial field cuts, anopias) and/or severe hearing deficit that would prevent use of the computerized treatment programParticipant with recent participation of computer-delivered cognitive training within 2 years of consentParticipant with claustrophobia or any other contraindication to MRI scanningParticipant with inability to complete a 1-hour MRIPregnant womenParticipant with any implanted devices above the waist (e.g., cardiac pacemaker or auto-defibrillators, neural pacemaker, aneurysm clips, cochlear implant, metallic bodies in the eye or central nervous system, any form of wires or metal devices that may concentrate radio frequency fields)Participants with active suicidal ideation with specific plan and intent or suicide-related behaviors within 2 months of consent as measured by the Columbia-Suicide Severity Rating Scale (C-SSRS)