Evaluating the Efficacy of Channa Striata in Stabilizing eNOS in Patients With Septic.

Sepsis is an inflammation response produced by the host's immune system, which is agrravated by oxidative stress. One of the adjuvant therapy according to Surviving Sepsis Campaign Guideline is albumin, which has anti-inflammatory and anti-oxidant effects. However, human albumin is quite expensive, and other forms with similar potency and less costs are needed, one of which is Channa striata extract. Therefore, this study is conducted to compare albumin and human albumin, specifically their anti- inflammatory and anti-oxidant properties by assessing the eNOS marker, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in patient with sepsis.

Inclusion Criteria:patients sepsis who met the qSOFA criteria ≧ 2 [two of which: unconsciousness (Glasgow Coma Scale ≤14)respiratory rate > 22 and systolic blood pressure ≤ 100 mmHg],aged ≧ 18 yearsadmitted to intensive care unit and high care unit at Dr. Moewardi General HospitalExclusion Criteria:patients with severe traumablood loss in stage three or higherstress ulcersa history of nephrotic syndromerefusal to participate