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Completed
NCT05562960
Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP
Conditions: Amyotrophic Lateral Sclerosis, Plasmapheresis
Sex: All
Ages: 20 Years – N/A
Healthy volunteers: No
Phase: NA
Enrollment: 5
Sponsor: National Taiwan University Hospital
Location: National Taiwan University Hospital Taipei
Summary
Patient with amyotrophic lateral sclerosis (ALS) having anti-NRIP autoantibody showed titer-dependent detrimental Effects. Plasmapheresis might benefit this subgroup of patients via removal of anti-NRIP autoantibody
Eligibility Criteria
Inclusion Criteria:
1. Patients with amyotrophic lateral sclerosis (ALS) at the age more than 20 years and having plasma anti-NRIP autoantibody.
2. Agree to receive plasmapheresis intervention.
3. Agree to participate in the trial and receive serial examinations and follow up.
Exclusion Criteria:
1. Patients without plasma anti-NRIP autoantibody.
2. Patients requiring permanent ventilator support for ALS progression.
3. Not able to receive plasmapheresis or trial-related examinations.
4. Under pregnancy.
5. Blood fibrinogen level less than 50 mg/dl.
6. Specific ALS subtypes, including primary lateral sclerosis, progressive muscular atrophy, flail arm syndrome, or flail leg syndrome.
Source: ClinicalTrials.gov (NCT05562960). StuddyBuddy aggregates publicly available trial information.
