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Completed
NCT05365477
Empiric Versus Selective Prevention Strategies for Kidney Stone Disease
Conditions: Kidney Stones, Nephrolithiasis
Sex: All
Ages: 18 Years – N/A
Healthy volunteers: No
Phase: PHASE4
Enrollment: 56
Sponsor: Vanderbilt University Medical Center
Location: Vanderbilt University Medical Center Nashville Tennessee
Summary
The aims of this study are to 1) Conduct a randomized clinical trial of selective versus empiric diet plus pharmacologic therapy in high-risk stone formers and 2) Determine adverse effects from, and adherence to selective and empiric strategies.
Eligibility Criteria
Inclusion Criteria:
* Two or more symptomatic kidney stone events in the last 5 years
* Adult
Exclusion Criteria:
* Medullary sponge kidney or renal tubular acidosis
* Untreated urinary obstruction
* Primary hyperparathyroidism
* Primary hyperoxaluria
* Pregnancy
* Inflammatory bowel disease or bowel resection
* Sarcoidosis
* Cystinuria
* Prior stone composition with uric acid, struvite, cystine, carbonate apatite
* Use of specific medications (thiazides, topiramate, xanthine oxidase inhibitors, citrate, bicarbonate)
* Chronic kidney disease stage 3 or higher (eGFR\
Source: ClinicalTrials.gov (NCT05365477). StuddyBuddy aggregates publicly available trial information.
