Post-Vent, the Sequelae: Personalized Prognostic Modeling for Consequences of Neonatal Intermittent Hypoxemia in Preterm Infants at Pre-School Age

Conditions: Premature Birth, Asthma in Children, Sleep-Disordered Breathing, Neurodevelopmental Disorders

Sex: All

Ages: 30 Weeks – 83 Months

Healthy volunteers: No

Enrollment: 500

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Location: Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois

Summary

Despite improved survival of extremely premature infants in recent decades, neonatal intensive care unit (NICU) graduates are diagnosed with asthma, sleep disordered breathing (SDB) in childhood, and neurodevelopmental impairments (NDI) at significant rates, disproportionate to their term peers. Early detection and intervention are critical to mitigate the impact of these impairments. Mechanisms leading from premature birth to these undesirable outcomes remain unclear, and accurate prognostic measures are lacking. This study wants to learn if these problems are related to certain patterns of breathing that babies had while they were in the NICU.

Eligibility Criteria

Inclusion Criteria: * Enrolled in any Institutional Review Board (IRB) protocol of the Pre-Vent Study that had signed consent, or in any IRB protocol of the Pre-Vent Study that authorized re-contact for future research * Born \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05336890). StuddyBuddy aggregates publicly available trial information.