Patient Derived Preclinical Models

Study goal is to collect tumor specimens that may inform cancer biology to eventually improve outcomes for patients with cancer. This proposal represents a highly collaborative effort to support cancer research with the goal of developing novel therapeutic strategies using patient derived preclinical models. This study is being done to collect samples of tumor tissues, matched normal tissue when possible, and approximately 50 mL of blood.

Inclusion Criteria: * 18 years of age and older * Patient is a good medical candidate for a standard of care or research biopsy or surgical procedure to obtain tissue Exclusion Criteria: * Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent * Institutionalized or incarcerated patients * Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use * Biopsy must not be considered more than minimal risk to the patient. * Have a contraindication to percutaneous biopsy including: 1. Significant coagulopathy that cannot be adequately corrected. 2. Severely compromised cardiopulmonary function or hemodynamic instability. 3. Lack of a safe pathway to the lesion per the interventional radiologist. 4. Inability of the patient to cooperate with, or to be positioned for, the procedure.