Addiction Intervention in Liver Transplantation Candidates

Addiction care is "a la carte treatment", adapted to the motivation and time constrains of users. Thus, various types of psychotherapeutic follow-up can be considered, different addictolytic medications or opioid maintenance therapies can be offered during treatment and hospitalization must be adaptable. In liver transplantation (LT), sustained alcohol relapse is a critical issue because it increases medium and long-term morbidity and mortality. In recent years, the issue of severe acute alcoholic hepatitis as an indication for LT has necessitated increased focus on appropriate alcohol monitoring around liver transplantation. Previously, alcohol consumption in pre- and post-LT period was mainly self-reported. More recently, the biological markers of excessive alcohol consumption have been validated in liver disease and can play a role in liver transplant recipients follow-up. The investigator hypothesize that standardized targeted addiction monitoring of LT patients decreases the rates of sustained alcohol relapse one year post liver transplantation.

Inclusion Criteria: * all adults undergoing pre-transplant assessment in the Liver Transplantation Unit of University Hospital of Montpellier, providing oral informed consent. Exclusion Criteria: * Patients under protection of justice or unable to receive a clear information. * Exclusion period determined by previous study * Pregnent women or breastfeeding * Patient under guardianship or curatorship * Not affiliated to french social security Removal of subjects from study criteria: * not registered on the liver transplant waiting-list or not transplanted during the study period * Liver transplantation prior to visit 1