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Recruiting NCT05317455

Regulation of Brain Glucose Metabolism in Type 1 Diabetes

Conditions: Diabetes Mellitus, Type 1, Hypoglycemia Unawareness

Sex: All

Ages: 18 Years – 55 Years

Healthy volunteers: No

Phase: EARLY_PHASE1

Enrollment: 16

Sponsor: Yale University

Location: Yale-New Haven Hospital New Haven Connecticut

Summary

This is a prospective randomized placebo-controlled double-blind crossover pilot study determining the effect of dichloroacetate on brain function under clamped hypoglycemia in T1DM.

Eligibility Criteria

Inclusion Criteria: T1DM subjects with: * a history of severe hypoglycemia and/or hypoglycemia unawareness or * a history of severe hypoglycemia with a blood glucose \85 kg at screening visit * BMI \> 30 (female) and \>30 (male) kg/m2. * Untreated proliferative retinopathy * carriers of glutathione transferase Z1 (GSTZ-1) gene polymorphisms that predispose to DCA accumulation and toxicity

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05317455). StuddyBuddy aggregates publicly available trial information.