Cardiac Impairments Following Pediatric Cardiotoxic Anti-cancer Treatment

This study aims at investigating the feasibility of recruitment and application of a method regarding early detection of subclinical changes in cardiac health after completion of acute cancer treatment during childhood and adolescence.

Inclusion criteria for all participants: * Aged between 10 and 25 years * Body height of ≥1,40m (required for performing the examination on the semi supine bicycle ergometer) * Signed informed assent (minor participant) and consent (legal guardian and full-aged participant) Additional inclusion criteria for participants following cancer treatment: * Completion of acute cancer treatment with anthracyclines and/or chest radiation * End of treatment 12 months and five years ago (± three months) * Medical approval for study participation Additional inclusion criteria for healthy control subjects: \- Appropriate as matched pair with respect to age and gender Exclusion Criteria: * Known cardiovascular diseases (incoherent with cardiotoxic treatment) * Inability to follow study instructions (e.g., mental retardation, language) * Acute orthopedic injury (e.g., bone fracture) or orthopedic impairments that preclude examination on a bicycle ergometer (e.g., instable prosthetic device) All participants receive a basic physical and cardiological examination at rest as part of the study protocol to ensure capability before performing the exercise stress echocardiography.