Candida PCR Diagnosis Strategy in Patients From Intensive Care Units

The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in patients from intensive care units with suspected systemic invasive candidiasis. This PCR method could allow an antifungal switch to be made earlier, limiting the appearance of resistance and reducing the cost of antifungals for healthcare facilities.

Inclusion Criteria: * Patient affiliated or benefiting from a social protection system * Patient (or his/her trusted person) having given free and informed written consent to the investigating physician * Non-neutropenic patient hospitalised in the Toulouse University Hospital intensive care unit. * Patient with suspected invasive candidiasis for whom a blood culture for fungal infection diagnosis was taken and for whom an empirical treatment with echinocandin at an adapted dose was implemented. Exclusion Criteria: * Patients under guardianship or trusteeship, persons under court protection * Pregnant or breastfeeding patients.