Exercise Effects on Adipose Tissue Structure and Function

Conditions: Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain

Sex: All

Ages: 18 Years – 40 Years

Healthy volunteers: No

Phase: NA

Enrollment: 46

Sponsor: University of Michigan

Summary

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

Eligibility Criteria

Inclusion Criteria: * Age: 18-40 * Body Mass Index: 27-45 kg/m2 * No regularly planned exercise/physical activity for at least 6 months * Women must have regularly occurring menses and must be premenopausal Exclusion Criteria: * Evidence/history of cardiovascular or metabolic disease * Medications known to affect lipid or glucose metabolism, or inflammation * Weight instability ≥ ± 6 pounds in the last 3 months * Tobacco or e-cigarette users * Women must not be pregnant or actively lactating

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT04812314). StuddyBuddy aggregates publicly available trial information.