INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit

The purpose of this study is to determine the efficacy of using a mobile health delivery unit ("mobile unit") to deliver "one stop" integrated health services - particularly medication for opioid use disorder (MOUD) and medication for HIV treatment and prevention - to people who inject drugs (PWID) with opioid use disorder (OUD) to improve uptake and use of MOUD, and uptake and use of antiretroviral therapy (ART) or pre-exposure prophylaxis (PrEP).

Inclusion Criteria: * At least 18 years of age * Urine test positive for recent opioid use and with evidence of recent injection drug use ("track marks") * Diagnosed with OUD per Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 * Able and willing to give informed consent * Willing to start MOUD treatment * Able to successfully complete an Assessment of Understanding * Self-reported sharing injection equipment and/or condomless sex in the last three months with partners of HIV-positive or unknown status * Able to provide adequate locator information * Confirmed HIV status, as defined in the HPTN 094 Study Specific Procedures Manual Exclusion Criteria: * Urine testing that is not negative for methadone within 30 days prior to Enrollment is exclusionary, unless verified hospital records show methadone received as a medication for hospitalization only during the screening period. A volunteer may provide a sample for urine testing more than once during the screening period in order to achieve a negative result. If this criterion cannot be met within 30 days from the start of screening, the individual will be considered a screen failure and the volunteer has up to two more screening chances to successfully complete the screening process again. * Received MOUD in the 30 days prior to enrollment by self-report * Co-enrollment in any other interventional study unless approved by the Clinical Management Committee (CMC)