Remote Monitoring in Progressive Supranuclear Palsy (PSP)

This is a single-arm, longitudinal, observational study on the use of wearable sensors and digital health technology to measure fall frequency and motor, speech, and cognitive function in patients with PSP over the course of approximately one year. Participants will perform supervised remote assessments monthly and in-person assessments approximately every 6 months.

Inclusion Criteria: * Clinical diagnosis of possible or probable PSP phenotype as defined by the 2017 MDS criteria, clinical diagnosis of at least probable PD as defined by the 2015 MDS criteria, or clinical diagnosis of at least probable MSA as defined by the 2022 MDS criteria, or healthy controls. * Male or female, aged 18 to 89 years, inclusive. * Fluent in reading and speaking English. * Capable of providing informed consent based on the investigator's judgment. * Able to comply with the protocol based on the investigator's judgment. * Able to walk 10 feet unassisted. * With access to a caregiver who is able to assist with all study-related procedures. Exclusion Criteria: * Any neurological, medical, or psychiatric condition that would preclude participation in study activities based on the investigator's judgment. * A history of frequent falls defined as more than 5 falls/month or requirement of a walker to ambulate safely.