Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients

The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation. The recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.

Inclusion Criteria: * Patients with focal drug-resistant epilepsy * Patients who undergo a presurgical evaluation with intracranial electrodes in the videoEEG unit of the Neurology department at the Pitié-Salpêtrière hospital. * Patients who have been informed and provided written informed consent to take part in the study Exclusion Criteria: * Contraindication for an intracranial investigation (with macro-electrodes) : intercurrent infectious syndrome, decompensated associated pathology (cardiac, pulmonary, renal, hepatic), patient with increased risk of infection (ex: under immunosuppressive therapy) * Pregnant or parturient woman * Breastfeeding woman * Minor person or legally protected adult (tutelage, legal guardianship, maintenance of justice)