Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women

Conditions: Coronary Disease, Percutaneous Coronary Intervention, Exercise Test, Myocardial Perfusion Imaging, Cardiac Catheterization

Sex: Female

Ages: 18 Years – N/A

Healthy volunteers: No

Enrollment: 500

Sponsor: Yale University

Location: Yale University School of Medicine - Section of Cardiology New Haven Connecticut

Summary

A real world study to evaluate outcomes in women based on guideline identified fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) cutoffs for ischemia (ischemia defined as FFR ≤ 0.80 and iFR ≤ 0.89).

Eligibility Criteria

Inclusion Criteria: 1. Female ≥ 18 years old at signing of informed consent 2. Suspected myocardial ischemia or acute coronary syndrome 3. Indication for non-invasive perfusion imaging study 4. Indication for diagnostic catheterization 5. Eligible for PCI 6. Signed informed clinical procedural consent by subject or by surrogate Exclusion Criteria: 1. Inability to receive adenosine or regadenoson (for example, severe reactive airway disease, marked hypotension, or advanced atrioventricular block without pacemaker. 2. Severe cardiomyopathy (ejection fraction \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT04599192). StuddyBuddy aggregates publicly available trial information.