Effects of Menthol in E-cigarettes on Smoking Behaviors

The overall goal of this proposal is to understand the relationship between nicotine metabolism and menthol flavor in e-cigarettes on smoking behavior in smokers.

Inclusion Criteria: * At least 21 years of age * Able to read and write English. * Smoking at least 1 menthol cigarettes/cigars/little cigars per day * Report regular menthol cigarette use * Have at least 200ng/ml urine cotinine * Willing to abstain from combustible tobacco products 12 hrs prior to each experimental session. * not planning a smoking quit attempt. * Have not stopped use due to COVID. * used e-cigarettes at least 10 times in the past six months. * Fully vaccinated against COVID-19. * must report history of JUUL and other nicotine salt/pod devices (i.e., JUUL-like) Exclusion Criteria: * Use of psychoactive drugs including anxiolytics, antidepressants, and other psychostimulants unless prescribed and stable for two months. * Current diagnosis of any severe psychiatric disorder * Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, pulmonary or hepatic pathology that would increase risk or would interfere with/mimic tobacco abstinence. * Known hypersensitivity to propylene glycol and nut allergies. * Pregnant or lactating females. * current criteria for moderate or severe cannabis and alcohol use disorder per DSM-5 criteria. * current criteria for other substance use disorders per DSM-5 criteria. * Seeking treatment to stop smoking. * individuals who do not want to use e-cigarettes. * Uncontrolled asthma (defined as \170/\>100 and heart rate \>100 * vaping of CBD/THC or marijuana related products in the past 3 months * For current THC vapers: Any report of mild or great EVALI-related symptoms (i.e. cough, shortness of breath, chest pain, nausea, vomiting, stomach pain, diarrhea, fever, chills, or weight loss) without non-EVALI reasonable and proximal cause