Tui-na and Oral Chinese Medicine on KOA

The study aims to evaluate the therapeutic effect of the Tui-na and oral Chinese medicine on the treatment of KOA. This is a prospective, randomized wait-list controlled trial in patients with knee osteoarthritis (KOA). After 2 weeks screening period, eligible subjects will be randomly assigned to the treatment group and wait-list control group in 1:1 ratio. Subjects will have 4-week of treatment, and then a 4-week follow-up.

Inclusion Criteria: 1. of either gender (female must have either sterilization done or menopause) 2. ≥50years of age 3. meet the criteria of KOA according to the American College of Rheumatology * Knee pain, and * Any 4 of the following, * ≥ 50 years of age * Less than 30 minutes of morning stiffness * Crepitus on active motion * Bony tenderness * Bony enlargement * No palpable warmth of synovium * Osteophytes (Radiographic findings) 4. with WOMAC score ≥ 39 5. with written informed consentform signed (for illiterate subjects, their next-of-kin or an impartial witness will sign with subjects' permission) Exclusion Criteria: 1. Known knee pain caused by infection, malignant or autoimmune diseases 2. Knee surgery or arthroscopy in the past year 3. Chondroprotective or intra-articular injection in the past 4 months 4. Systemic corticoid treatment in the past 4 months 5. Taking anticoagulants, antiplatelets, corticosteroids, psychiatric drugs, hormones, antiarrhythmic drugs or diuretics drugs 6. Subject with uncontrolled hypertension 7. Local antiphlogistic treatment, acupuncture, physiotherapy in the past 2 weeks 8. Known history of mental disorder 9. Known history of serious acute organic disease 10. Renal or liver function impairment 11. Known allergy to or have drug interaction with the study herb