Human Cerebral Blood Flow Regulation

Sex: All

Ages: 18 Years – 40 Years

Healthy volunteers: Yes

Phase: EARLY_PHASE1

Enrollment: 42

Sponsor: University of Wisconsin, Madison

Summary

To determine cerebrovascular control mechanisms in humans and provide mechanistic knowledge to offer new sex-specific therapeutic options for cerebrovascular diseases. The current objective is to determine how sex and sex hormones influence CBF control in healthy young adults without confounds of age or disease. The central hypothesis is men exhibit reduced cerebral vasodilator function due in part to differences in COX signaling compared to women. Comprehensive CBF data from multi-modal MRI indicate the magnitude of sex differences-as well as the vasodilator mechanisms-are regionally distinct. Research confounding variables like aging and disease will be mitigated by comparing younger adults (18-40 years old).

Eligibility Criteria

Inclusion Criteria: * All participants will be healthy adults between 18-40 years old, matched for age and aerobic fitness * Participants will be non-hypertensive (\

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT04265053). StuddyBuddy aggregates publicly available trial information.