Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy

Conditions: Lumbar Disc Herniation

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: No

Phase: PHASE4

Enrollment: 200

Sponsor: University of Missouri-Columbia

Location: Missouri Orthopaedic Institute Columbia Missouri

Summary

The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.

Eligibility Criteria

Inclusion Criteria: * Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation * Failed conservative treatment - rest, anti-inflammatory medications, physical therapy * Radiculopathy present - positive tension signs or sensory/motor neurologic deficits present * Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation Exclusion Criteria: * Concomitant spinal stenosis, segmental instability, or spondylolisthesis * Previous surgery at the affected level or recurrent herniation * Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression * Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment * Diagnosis of or symptoms concerning for cauda equina syndrome

Interested in this study? View the official listing for contact and enrollment details.

View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT04182997). StuddyBuddy aggregates publicly available trial information.