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NCT04150198
MECHANISMS OF NEURONAL RESILIENCE IN ALZHEIMER'S DISEASE AND ITS FOCAL VARIANTS: A PET/MR STUDY
Conditions: Alzheimer Disease, Early Onset, Posterior Cortical Atrophy
Sex: All
Ages: 40 Years – 80 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 45
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France
Location: Service Hospitalier Frédéric Joliot SHFJ Orsay
Summary
Patients with Alzheimer's disease and with early onset of symptoms (\
Eligibility Criteria
Inclusion Criteria:
1. For all subjects:
* Affiliation to a social security insurance or beneficiary
* Informed consent form signed by the participant or his / her legal representative
* Participants aged 40 to 80 years.
2. Selection of AD-Y group
\- In vivo proof of Alzheimer's pathology:
* Determination of specific proteins on the cerebrospinal fluid (CSF, a routine care procedure). The values considered pathological (AD) are Aβ1-42 peptide \ 450 and phosphorylated tau protein\> 60, IATI index \ 1.23 as well as phosphorylated tau protein / Aβ1-42\> 0.211.
* And / or a positive PET-amyloid imaging test.
* Early-onset episodic memory deficit (\
Source: ClinicalTrials.gov (NCT04150198). StuddyBuddy aggregates publicly available trial information.
