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Active Not Recruiting
NCT04149600
Identification of Genetic Causes of Calcific Aortic Valve Disease
Conditions: Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency
Sex: All
Ages: 20 Years – N/A
Healthy volunteers: Yes
Enrollment: 1000
Sponsor: Beth Israel Deaconess Medical Center
Location: Beth Israel Deaconess Medical Center Boston Massachusetts
Summary
This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
Eligibility Criteria
Inclusion Criteria:
* Patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery
Exclusion Criteria:
* Age \< 20 years
* Unable/unwilling to consent
* History of aortic valve replacement or transcatheter aortic valve replacement (TAVR)
* History of endocarditis
* History of rheumatic fever
* History of chest radiotherapy
* History of organ transplant
Source: ClinicalTrials.gov (NCT04149600). StuddyBuddy aggregates publicly available trial information.
