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Completed
NCT04125589
Decision Making, Daily Experiences, and Brain Activity in Young Adult Women
Conditions: Binge-Eating Disorder
Sex: Female
Ages: 18 Years – 40 Years
Healthy volunteers: Yes
Phase: NA
Enrollment: 77
Sponsor: Mclean Hospital
Location: McLean Hospital Belmont Massachusetts
Summary
The investigators are doing a study of women with and without binge-eating disorder to learn more about what happens when people engage in everyday decision-making activities. The investigators are interested in learning more about brain activity during everyday decision-making and how everyday decision-making relates to a variety of daily experiences. Examples of everyday decisions include deciding which product to buy, deciding what to eat for a snack, and deciding how to spend free time.
Eligibility Criteria
INCLUSION CRITERIA:
Inclusion Criteria for All Participants:
* Normal or corrected to normal vision and hearing
* Verbal and written fluency in English
* Right-handed
* Body mass index of 20-35 kg/m\^2
Additional Inclusion Criteria for Participants with Binge-Eating Disorder:
• DSM-5 binge-eating disorder
EXCLUSION CRITERIA:
Exclusion Criteria for All Participants:
* Impaired cognition or other neurological/cognitive problems
* Contraindications to MRI (e.g., certain metal implants, claustrophobia)
* Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding
* Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions
* Recent low weight
* Certain medications (e.g., insulin)
* Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence
* Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods
* Current/recent suicidality
* Current/recent changes in treatment for mental illness
* Study-relevant research experience
Additional Exclusion Criteria for Comparison Participants:
* Personal history of eating disorders or recurrent binge eating
* Personal history of any other mental illness, including serious substance use problems
* First-degree relative with current or past eating or psychotic disorder
* Significant recent change in weight
Additional Exclusion Criteria for Participants with Binge-Eating Disorder:
* Severe mental illness (e.g., psychotic disorder, severe agoraphobia)
* Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety
* Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder
Source: ClinicalTrials.gov (NCT04125589). StuddyBuddy aggregates publicly available trial information.