Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix

This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.

Inclusion Criteria: For control group: * Age between 20 and 65 years * Patients hospitalized for partial or total removal of the cervix * Absence of cervical lesion observed on biopsy or hysterectomy * Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study) * Affiliate or beneficiary of a social security scheme For dysplasia and cancer group: * Age between 20 and 65 years * Cervical Intraepithelial Neoplasia or previously untreated cervical cancer * Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study) * Affiliate or beneficiary of a social security scheme Exclusion Criteria: For control group: * History of laser or conisation * Known antecedent of HIV infection * Congenital or acquired immunodepression * Long-term treatment with corticosteroids or immunosuppressants * Persons placed under the protection of justice For dysplasia and cancer group: * History of laser or conisation * Pre-treatment of invasive cancers by radiotherapy or chemotherapy * Known antecedent of HIV infection * Congenital or acquired immunodepression * Long-term treatment with corticosteroids or immunosuppressants * Persons placed under the protection of justice