Optimizing Long-term Survival in Organ Transplantation: From Physiopathology to Optimized Patient Management

Increased indications for transplantation continue to worsen the shortage of organs and need the extension of graft sampling criteria and the search for new potential sources of organs. Despite undeniable success in the short term, due to major advances in surgery, medicine and research, transplant recipients continue to face the risk of chronic rejection and long-term complications. The University Hospital Federation "FHU SUPORT" was created to optimize the chances of success of the organ transplant and improve the quality of life of the transplanted patient. FHU SUPORT 's ambition is based on a translational strategy that presents two priority areas: Axis 1: Optimization, evaluation, conditioning of the donor, graft, recipient Axis 2: Personalized follow-up of the transplanted patient in the short and long term Identifying factors for long-term graft and patient survival through translational research from a common cohort and biological collection will predict transplant rejection, prolong graft function, or improve the patient's care.

Inclusion Criteria: * Male or female over 18 (no age limit) * affiliated to a social security organization * Recipient (s) of a kidney, liver or heart transplant * followed by at least one of the FHU SUPORT centers (Tours, Poitiers, Limoges, Rennes) * having given informed consent to participate in the cohort. Exclusion Criteria: * Patient unable to understand the information given by the investigator * People under the protection of justice