Neuroinflammation After Myocardial Infarction - Imaging Substudy

The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called \[18F\]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain inflammation in heart disease and develop new treatments to protect the brain.

Inclusion Criteria: 1. Participation in UAB IRB protocol "Neuroinflammation After Acute Myocardial Infarction" (IRB-300002751, PI Lazar). 2. 21 years of age or older 3. . English speaking with at least 8th grade education 4. High or mixed affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971. 5. Admission to UAB Hospital for ST-elevation acute myocardial infarction (AMI) and treatment with percutaneous coronary intervention (PCI) OR Undergoing elective percutaneous coronary intervention (PCI) Exclusion Criteria: 1. Contraindication to MRI 2. Pregnancy 3. Lactation 4. Serious medical co-morbidity that may interfere with participation 5. Prior myocardial infarction 6. Severe anemia 7. Prior coronary artery bypass grafting 8. Prior angioplasty and/or coronary artery stent placement (PCI group only) 9. History of traumatic head injury defined by a loss of consciousness ≥30 minutes or seizure at the time of injury 10. Diagnosis of major depression 11. Diagnosis of dementia 12. Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.