ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer

ABCSG C08 is a randomized, two-arm, multicenter trial to investigate the efficacy of endurance exercise following adjuvant chemotherapy in patients with colorectal cancer. Indication: Locally advanced colorectal cancer after adjuvant chemotherapy. Evidence supporting the beneficial effects of exercise programs during chemotherapy are available, the results across studies are not entirely consistent. Additional studies are needed to determine the optimal content, intensity, and form of training programs.

Inclusion Criteria: * completely resected, histologically confirmed adenocarcinoma of the colon or rectum * patients, who have completed adjuvant chemotherapy 4-16 weeks prior to randomization * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 * Age ≥18 years * adequate hematologic functions \150 minutes (type of physical activity: bicycling, cross walking (cross trainer), jogging, walking at a brisk pace, nordic walking, cross country skiing) within the last year before diagnosis of colorectal cancer * patients unwilling to complete endurance exercise or complete all questionnaires related to the study * past or current history of other malignant neoplasms other than colorectal cancer in the last 5 years except basal cell carcinoma of the skin and/or in situ carcinoma of the cervix * clinically significant cardiovascular disease * left bundle branch block * current study with chemotherapy or radiation * current pregnancy or plans to become pregnant within the next 3 years