Minimally-invasive Non-surgical Therapy of Intrabony Defects

This investigation aims to assess the clinical and radiographic outcomes of intrabony defects treated with minimally-invasive non-surgical therapy.

Inclusion Criteria: 1. Age 18-70 2. Diagnosis of Periodontitis (Tonetti et al. 2018) 3. Presence of ≥1 'intrabony defect' (PPD and CAL \>5 mm with radiographic intrabony defect depth ≥3mm and not in a site associated with furcation involvement) 4. Signed informed consent \[Participants must be able and willing to read and sign a copy of the "Informed Consent Form" (ICF) form after reading the "Patient Information Leaflet" (PIS), and after the nature of the study has been fully explained\]. Exclusion Criteria: 1. Smoking (current or in past 5 years, including electronic cigarettes, vaping or similar) 2. Medical history including diabetes or hepatic or renal disease, or other serious medical conditions or transmittable diseases 3. Presence of drug-induced gingival enlargement 4. History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures 5. Anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam 6. Systemic antibiotic therapy during the 3 months preceding the baseline exam, 7. Taking immunosuppressant medications 8. Known allergy to local anaesthetic 9. History of alcohol or drug abuse 10. Self-reported pregnancy or lactation 11. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that according to the investigator may increase the risk associated with trial participation 12. Periodontal treatment to the study site within the last 12 months (excluding not-extensive subgingival debridement as judged by the examining clinician).