Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Conditions: Heart Failure With Normal Ejection Fraction, Heart Failure With Reduced Ejection Fraction, Heart Failure, Right Sided, Heart Failure With Mid Range Ejection Fraction, Cardiovascular Risk Factor

Sex: All

Ages: 18 Years – N/A

Healthy volunteers: Yes

Enrollment: 3000

Sponsor: Massachusetts General Hospital

Summary

In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

Eligibility Criteria

Inclusion criteria for patients with HF: * 18 years and older * History of clinical symptoms consistent with HF and at least one of the following supporting evidence of HF: * NT-proBNP \> 125 pg/mL * BNP \> 35 pg/mL * Capillary wedge pressure ≥ 15 mmHg on right heart catheterization or CI \

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT03480633). StuddyBuddy aggregates publicly available trial information.