Comparison of Cervical CIN II/III Treatment Outcomes With Thermal Ablation Device

The purpose of this academic-industrial partnership will be to compare two thermoablation modalities using devices adapted to low and middle income countries (LMICs) to traditional CO2-based cryotherapy for the treatment of cervical precancer. The investigators will investigate whether the cure rates of cervical intraepithelial neoplasia 2 and more severe diagnoses (CIN2+) with these devices are non-inferior compared to that of conventional cryotherapy. The results of this study will affect other research areas by serving as a springboard to exploring treatment alternatives that are amenable to low-resource settings and thus will reach the most vulnerable populations.

Criteria for inclusion * Women aged 18 and older * Biopsy results of CIN2, CIN2-3, CIN3, or high-grade CIN not otherwise specified * Willing and able to provide informed consent * Willing and able to provide permanent or reliable address Criteria for exclusion * Pregnant or plans to become pregnant during study * History of total hysterectomy (verified by medical record or pelvic evaluation) * Previous surgery destructive to the cervix within the last 5 years * Patient not eligible for cryotherapy or thermoablation (lesion \>75% of cervix, lesion extends into canal or there is suspicion for invasive cancer) * Cervix shape disfigured or hard to reach