Peri-implantitis - Reconstructive Surgical Therapy

The project will evaluate the potential benefit of the use of bone replacement graft as an adjunct to surgical therapy of peri-implantitis. The project will be conducted as a two-armed randomized controlled clinical trial of 5-year duration in 7 clinical centers. 140 systemically healthy patients diagnosed with peri-implantitis will randomly assigned to be treated with or without bone replacement graft. Outcome measures include assessments of inflammation, probing depth, recession, radiological parameters and PROMs.

Inclusion Criteria: * Age ≥ 18 years * ≥1 implant (≥1 year of function) presenting with PPD ≥7 mm and BoP/Pus. * Confirmed bone loss ≥3 mm at same implant(s) Exclusion Criteria: * Treated for peri-implantitis during previous 6 months * Intake of systemic or local antibiotics during previous 6 months * Systemic conditions affecting peri-implant tissues * Systemic conditions impeding surgical intervention