Cerebral Amyloid Imaging Using Florbetapir (AV-45)

This study is aimed at examining the interest of amyloid radiotracer Florbetapir (18F-AV-45) for the etiological diagnosis of poststroke cognitive impairment and dementia

Inclusion Criteria: 1. patients suffering of parenchymal stroke visualized by imaging (MRI), 2. patients suffering from cognitive impairment on the 6 months assessment (including GRECogVASC patients), 3. age between 40 and 80 years, 4. French-speaking, 5. reliable informant, 6. agreeing to participate in the study, 7. affiliation to a social security system, Exclusion Criteria: 1. women of childbearing potential (defined as pre-menopausal, less than 2 years postmenopausal, or not surgically sterile), or who are breast-feeding 2. history of relevant severe drug allergy or hypersensitivity, 3. patient receiving any investigational medications at least in the 30 last days, 4. stroke affecting the cerebellum, 5. mental retardation, 6. illiteracy, 7. dementia diagnosed before stroke, 8. history of schizophrenia or psychiatric illness requiring a stay for \> 2 days in a psychiatry unit, 9. persons placed under judicial protection, 10. comorbidities affecting cognition (respiratory, renal, liver, heart failure), 11. persistent disturbance of consciousness defined by a score to item 1a of the National Institute of Health Stroke Scale (NIHSS) ≤ 1, 12. contraindication to MRI.