Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction

Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.

Inclusion Criteria: * First ST Elevation Myocardial Infarction * Primary Percutaneous Coronary Intervention (TIMI 3) * Single vessel coronary artery disease * Age over 18 years * Informed Consent dated and signed * Written and spoken French * Beneficiary of social security insurance Exclusion Criteria: * No Primary Percutaneous Coronary Intervention * TIMI 0-2 after Primary Percutaneous Coronary Intervention * Significant two or three-vessel coronary artery disease (\> 70% stenosis in at least one of the other two coronary arteries) * Past history of myocardial infarction before STEMI * Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure * Pregnant and / or lactating * Age under 18 years or guardianship