Early Identification of Patients Presenting a First Psychotic Episode, Non Answering to First Line Support Strategies

Researchers propose in this project to evaluate predictive factors of non response. It is defined by the lack of symptomatic remission at month 3, for patients presenting a first episode of psychosis. It will be performed on objective markers taken from imagery techniques. The link between evolution of these markers and clinical measures will be studied.

Inclusion Criteria: * men and women aged 18-35 years * member or beneficiary of a social security scheme, * for women, appropriate contraception will be mandatory, as well as a negative pregnancy test, * patients with a diagnosis of schizophrenia, schizoaffective disorder or schizophreniform disorder according to the DMS V * having never received anti-psychotic treatment, * followed in the hospital or outpatient, * having given their written informed consent, * that the physical examination revealed no significant clinical abnormalities Exclusion Criteria: * Female patients of childbearing period without effective contraception (oral, intramuscular hormonal, intrauterine device, or surgical); * Patients pregnant or nursing; * Presenting a serious somatic or neurological disease, especially Parkinson's disease, epilepsy, debilitating tardive dyskinesia, cardiovascular disease, severe liver or kidney; * Featuring against-indication for an MRI; including: metallic foreign body eye or intracranial, pacemaker, heart valve, surgical clips, claustrophobia, large tattoo in the upper part of the body, not compatible with 3T MRI * Having a history of alcohol or drug abuse in the past year; * Participating in another clinical trial or being in an exclusion period of the previous protocol; * Patients likely to exhibit aggressive behavior self according to the judgment of the investigators.