Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans

Sex: All

Ages: 20 Years – 50 Years

Healthy volunteers: Yes

Phase: PHASE1

Enrollment: 27

Sponsor: Vanderbilt University Medical Center

Summary

The overall hypothesis of this proposal is that nutrient sensing in the foregut regulates metabolic hormone secretion and nutrient metabolism via enteric neural signals, and these mechanisms might be defective in obesity.

Eligibility Criteria

Inclusion Criteria: * BMI 19 - 25 kg/m2 or 30 - 50 kg/m2 * Age 20 - 50 years Exclusion Criteria: * Contraindication to a nasoduodenal feeding tube (e.g., deviated nasal septum, prior upper gastrointestinal bleed, or history of easy bleeding) * Prior gastric or intestinal surgery or pancreas resection * Females with a positive pregnancy test * Known history of intestinal diseases including, but not limited to, inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease), celiac sprue * Type 1 or type 2 diabetes * Recent presence of or treatment for gastroenteritis (diarrhea and/or vomiting), constipation, or upper respiratory infection * Anemia * Abnormal electrocardiogram * Prior adverse reaction to anesthesia * Tobacco use

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT02537314). StuddyBuddy aggregates publicly available trial information.