Comparison of Sensitivity Between Presepsine and Lactate for the Diagnosis of Severe Sepsis.

Severe sepsis and sepsis shock are common in emergency department, with a high mortality rate. The potential severity of this disease impose a diagnosis as early as possible to start antibiotic therapy and hemodynamic support. Conventional biomarkers are an important support for the emergency physician. However, comparison of sensitivity and specificity for new biomarkers, like presepsine, suggests that they can be more efficient in this area. In this single-center, prospective, non-interventional study, we propose to compare the sensitivity of presepsine to that of lactate for the diagnosis of severe sepsis and septic shock We emit to main hypothesis that the sensitivity of presepsine is higher than that of lactate for the diagnosis of severe sepsis.

Inclusion Criteria: * Age\> 18 years * Presence of at least two SIRS criteria (T °\> 38.3 ° or \ 90 / min, tachypnea\> 20 / min, recent alteration of consciousness) * Suspected Infection * Indication of an arterial lactate assay on medical advice * Affiliation to social security * Informed Consent Exclusion Criteria: * Renal dialysis * Scalable neoplasia chemotherapy * Patient Palliative Care * Private Patient freedom or under legal protection