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Completed NCT02083822

Cerebral Abnormalities Detected by MRI, Realized at the Age of Term and the Emergence of Executive Functions

Conditions: Premature Baby 25 to 32 Weeks

Sex: All
Ages: 25 Weeks – 32 Weeks
Healthy volunteers: No
Phase: NA
Enrollment: 600
Sponsor: University Hospital, Tours

Location: Service de Neurologie Pédiatrique Angers

Summary

The survival of premature babies increased during the last decades. However, the neurocognitive long term development of these children is worrying, as demonstrated by EPIPAGE 1 study. These children present high risk of deficits such as cognitive deficits, adaptive malfunction, behavior disorders and difficulties in school learning. Understanding the specific neuropsychological disorders at the origin of these deficits is an important objective. Studies realized at school age showed that many premature children have executive functions (EF) disorders. However the specific nature of these disorders and the neuropathology associated are unknown. The aim of this study is to realise MRI at term age in preterm babies born less than 32 GA and to correlate MRI findings with executives functions and neurodevelopmental outcome

Eligibility Criteria

Inclusion Criteria Infants who were : * born between 25 and 32 WGA * hospitalized in a neonatology service which participate to the present study * included in EPIPAGE 2 follow-up study * infants whose parents had signed the consent agreement and benefit from national health insurance Exclusion Criteria * Infants with congenital abnormalities

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT02083822). StuddyBuddy aggregates publicly available trial information.