A Pilot Study Testing Onabotulinum Toxin A Versus Incobotulinum Toxin A Injections for Facial Wrinkles

The purpose of this study is to compare the effectiveness of Botox® (Onabotulinum Toxin A) versus Xeomin® (incobotulinum toxin A) for the treatment of forehead and glabellar (vertical lines between the eyebrows) wrinkles.

Inclusion Criteria: 1. Females and males 2. In good health 3. Is 20-65 years of age 4. Has static and moderate dynamic forehead/glabellar wrinkles 5. Has willingness and the ability to understand and provide informed consent and communicate with the study staff Exclusion Criteria: 1. Pregnant or lactating 2. Younger than 20 or older than 65 years of age 3. Has received the following treatments in the forehead or glabellar region: 1. botulinum toxin injections in the past 6 months 2. ablative laser procedure in the past 6 months 3. radiofrequency device treatment in the past 6 months 4. ultrasound device treatment in the past 6 months 5. medium to deep chemical peel in the past 6 months 6. temporary soft tissue augmentation material in the area to be treated in the past year 7. semi-permanent soft tissue augmentation material in the area to be treated in the past 2 years 8. permanent soft tissue augmentation material in the area to be treated 4. Is planning to receive within the next 6 months, any cosmetic procedure (such as any chemical peels, botulinum toxin injections, ablative or non-ablative laser procedures, filler injections, radiofrequency procedures, dermabrasion, ultrasound and face lifting procedures) in the forehead or glabellar region. 5. Is planning to use tretinoin or retinoic acid in the next 6 months 6. Has an active infection in the forehead or glabellar region (excluding mild acne) 7. Is allergic to cow's milk protein 8. Is allergic to albumin 9. Taking aminoglycoside 10. Is currently using anticoagulation therapy 11. Has a history of bleeding disorders 12. Has a mental illness 13. Unable to understand the protocol or to give informed consent