Bone Loss in Patients With Anorexia Nervosa

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences. 160 patients (age \< 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

Inclusion Criteria: * Informed Consent * Health Insurance regimen or benefit from an health insurance regimen * Aged from 14 to 38 years old * Women * No pregnant Specific inclusion criteria for patient: Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Specific inclusion criteria for controls: * Normal menstrual cycles, * No lifetime history of eating disorders, * BMI between 18 and 25 kg/m² Exclusion Criteria: * use of treatments may be modify bone mass (bisphosphonates,…) * Disease or treatment may be induce osteoporosis * In exclusion period in relation with another study * Law protected subject