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Completed
NCT01858896
GLP-1 and Hypoglycemia
Conditions: Type 2 Diabetes Mellitus
Sex: All
Ages: 18 Years – 45 Years
Healthy volunteers: Yes
Phase: EARLY_PHASE1
Enrollment: 28
Sponsor: University of Maryland, Baltimore
Location: University of Maryland, Baltimore Baltimore Maryland
Summary
Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels. The purpose of this study is to learn if and how glucagon-like peptide-1 (GLP-1; a naturally occurring hormone in the gut) changes the effects that low blood sugar levels have on blood vessels.
Eligibility Criteria
Inclusion Criteria:
* 14 (7 males, 7 females) healthy controls age 30-60 yr.
* 14 (7 males, 7 females) people with type 2 DM age 30-60 yr.
* For type 2 DM: HbA1c 6-10.0%
* No significant diabetic tissue complications (i.e. history of retinopathy, neuropathy, stasis ulcers, etc.)
* Body mass index \>25kg • m-2
Exclusion Criteria:
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Source: ClinicalTrials.gov (NCT01858896). StuddyBuddy aggregates publicly available trial information.
