Role of Fibrocytes in Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a frequent airway disease characterized by both bronchial inflammation and remodelling. Bronchial mucosa is infiltrated by macrophages, neutrophils and lymphocytes. In addition, the number of eosinophils can be also increased during exacerbation. Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of COPD and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.

Inclusion Criteria: * Patients: diagnostic of Chronic obstructive pulmonary disease (COPD) exacerbation. * Control group: subjects without any history of lung disease and with normal lung function testing. Subjects will be separated in 2 sub-groups according to smoking history (Never smokers, smokers (former or current) and paired to patients according to age and sex. * Written informed consent Exclusion Criteria: * Subject without any social security or health insurance * Asthma, lung fibrosis or idiopathic pulmonary hypertension * Chronic viral infections (hepatitis, HIV)