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Terminated NCT00158535

Liver Transplantation in Patients With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Coinfection

Conditions: HIV Infections, Hepatitis C

Sex: All

Ages: 18 Years – 69 Years

Healthy volunteers: No

Phase: PHASE2

Enrollment: 15

Sponsor: ANRS, Emerging Infectious Diseases

Location: Centre hepato biliaire hopital paul Brousse Villejuif

Summary

To show the feasibility of liver transplantation in HCV-HIV coinfected patients. To study the two-year survival after transplantation, the interaction between HCV and HIV after transplantation, the influence of HIV on HCV recurrence after transplantation, the interaction between immunosuppressive and antiretroviral drugs in particular anti-proteases, immunological follow-up and quality of life of these patients

Eligibility Criteria

Inclusion Criteria: * Coinfection HIV-HVC * Indication of liver transplantation for severe hepatopathy with life threatening:repetitive ascitis or infection of ascitis or icterus or decreased of prothrombin index under 50 percent or digestive haemorrhage by portal hypertension uncontrolled Exclusion Criteria: * Toxicomania * Alcohol consumer (over 30g per day) * AgHBs positive * hepatocarcinoma over 5 cm or 3 nodules * CD4 below 200/mm3 * Viral load below 400 cp * HIV stade C

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT00158535). StuddyBuddy aggregates publicly available trial information.